This gene is a member of the Insulin-like growth factor-binding protein ( IGFBP ) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain.
32.
Small globules of the follicular colloid ( Tg ) are endocytosed ( hormone ( TSH )-mediated ) and proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4 within the thyrocyte cytoplasm.
33.
Caution, however, should be exercised in interpreting thyroglobulin results without thyroglobulin antibodies, since thyroglobulin antibodies commonly interfere in thyroglobulin immunoassays causing false positive and negative results which may lead to clinical misdirection.
34.
Caution, however, should be exercised in interpreting thyroglobulin results without thyroglobulin antibodies, since thyroglobulin antibodies commonly interfere in thyroglobulin immunoassays causing false positive and negative results which may lead to clinical misdirection.
35.
Caution, however, should be exercised in interpreting thyroglobulin results without thyroglobulin antibodies, since thyroglobulin antibodies commonly interfere in thyroglobulin immunoassays causing false positive and negative results which may lead to clinical misdirection.
36.
Caution, however, should be exercised in interpreting thyroglobulin results without thyroglobulin antibodies, since thyroglobulin antibodies commonly interfere in thyroglobulin immunoassays causing false positive and negative results which may lead to clinical misdirection.
37.
Under the guidance of Antoine Lacassagne, Leblond injected radioiodine-128, into a rat and found that the label promptly accumulated in the thyroid gland, presumably incorporated into the thyroid hormone precursor thyroglobulin.
38.
In 1956, together with Deborah Doniach and Peter Campbell, he made the classic discovery of thyroglobulin autoantibodies in Hashimoto's thyroiditis which helped to open the whole concept of a relationship between autoimmunity and human disease.
39.
EpCAM consists of an extracellular domain ( 242 amino acids ) with epidermal growth factor ( EGF )-and thyroglobulin repeat-like domains, a single transmembrane domain ( 23 amino acids ), and a short intracellular domain ( 26 amino acids ).
40.
Other bioactive RiPPs include the antibiotics cyclothiazomycin and bottromycin, the ultra-narrow spectrum antibiotic plantazolicin, and the cytotoxin patellamide A . Streptolysin S, the toxic virulence factor of " Streptococcus pyogenes ", is also a RiPP . Additionally, human thyroid hormone itself is a RiPP due to its biosynthetic origin as thyroglobulin.
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