1. Thyroglobulin is not produced by medullary or anaplastic thyroid carcinoma.2. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.3. If successful, thyroglobulin should be undetectable. 4. Iodine in the bloodstream is taken up by the gland and incorporated into thyroglobulin molecules. 5. The thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland. 6. However, the breakdown of thyroglobulin produces 6-7 fold more iodinated tyrosines than thyroid hormone. 7. A subsequent elevation of the thyroglobulin level is an indication of recurrence of papillary or follicular thyroid carcinoma. 8. Within the thyroid follicular cell, thyroglobulin is hydrolyzed to form thyroid hormones and mono-and diiodotyrosine. 9. When the follicular cells are stimulated by thyroid-stimulating hormone, the follicular cells reabsorb thyroglobulin from the follicular space. 10. Lastly, antibodies against components of the thyroid, particularly anti-TPO and anti-thyroglobulin , can be measured.
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