41. This suggests autophagy induction in gliomas could be caused by micro-environmental changes. 42. The mTOR pathway normally inhibits autophagy , as is induced by heightened glucose uptake. 43. Therefore, decreasing glucose levels should suppress the mTOR pathway, allowing for autophagy . 44. Autophagy is when a cell digests some of its own organelles by lysosomal degradation.45. It strongly inhibits telomerase and stimulates multiple mechanisms including apoptosis, autophagy and senescence. 46. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.47. Proteins involved in autophagy are reduced with age in both human and mouse articular cartilage. 48. These results suggest autophagy is a normal protective process ( chondroprotection ) in the joint. 49. The role of autophagy in cancer is one that has been highly researched and reviewed. 50. Moreover, Parkin is described to be necessary for mitophagy ( autophagy of mitochondria ).
