41. This changes chromatin conformation to expose the transcriptional domain. 42. The Orc1 associated with chromatin is released during mitosis. 43. Chromatin remodeling is essential for many processes including transcription.44. Both Ikaros and Aiolos can participate in chromatin remodeling. 45. The Xist chromatin binding region was first elucidated in female mouse fibroblastic cells. 46. This complex is required for the conversion of interphase chromatin into condensed chromosomes. 47. Chromatin association of cohesin is not sufficient for cohesion.48. Sororin also has chromatin binding activity independent of its ability to mediate cohesion. 49. This DNA is wound around proteins to form a structure known as chromatin . 50. His group are interested in the mechanisms which remodel and alter chromatin structure.