The "'denaturant binding model "'assumes that there are specific but independent sites on the protein molecule ( folded or unfolded ) to which the denaturant binds with an effective ( average ) binding constant " k ".
42.
The "'solvent exchange model "'( also called the weak binding model or selective solvation ) of Schellman invokes the idea of an equilibrium between the water molecules bound to independent sites on protein and the denaturant molecules in solution.
43.
Ions that have a strong'salting in'effect such as I " and SCN " are strong denaturants, because they salt in the peptide group, and thus interact much more strongly with the unfolded form of a protein than with its native form.
44.
Ions that have a strong " salting in " effect such as I " and SCN " are strong denaturants, because they salt in the peptide group, and thus interact much more strongly with the unfolded form of a protein than with its native form.
45.
The fitting variables A _ { N } and A _ { U } are sometimes allowed to vary linearly with the solution conditions, e . g ., temperature or denaturant concentration, when the asymptotes of A are observed to vary linearly under strongly folding or strongly unfolding conditions.
46.
In fitting to a two-state model, the logarithm of the folding and unfolding rates is assumed to depend linearly on the denaturant concentration, thus resulting in the slopes m f and m u, called the folding and unfolding m-values, respectively ( also called the kinetic m-values ).
47.
A number of models have been proposed to explain this observation prominent among them being the "'denaturant binding model "', "'solvent-exchange model "'( both by John Schellman ) and the "'Linear Extrapolation Model "'( LEM; by Nick Pace ).
48.
Acetic acid is a denaturant that is sometimes used in combination with the other precipitating fixatives, such as Davidson's AFA . The alcohols, by themselves, are known to cause considerable shrinkage and hardening of tissue during fixation while acetic acid alone is associated with tissue swelling; combining the two may result in better preservation of tissue morphology.
49.
This model tries to answer the question of whether the denaturant molecules actually bind to the protein or they " seem " to be bound just because denaturants occupy about 20-30 % of the total solution volume at high concentrations used in experiments, i . e . non-specific effects and hence the term weak binding.
50.
This model tries to answer the question of whether the denaturant molecules actually bind to the protein or they " seem " to be bound just because denaturants occupy about 20-30 % of the total solution volume at high concentrations used in experiments, i . e . non-specific effects and hence the term weak binding.
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