The hybrid dysgenesis phenotype is affected by the transposition of P elements within the germ-line cells of offspring of " P strain " males with " M strain " females.
42.
In addition to agenesis of the corpus callosum, other callosal disorders include hypogenesis ( partial formation ), dysgenesis ( malformation ) of the corpus callosum, and hypoplasia ( underdevelopment ) of the corpus callosum.
43.
XX gonadal dysgenesis is related to the Swyer syndrome inasmuch as both conditions have the same phenotype and clinical issues; however in Swyer syndrome the karyotype is 46, XY, and thus gonadectomy is recommended.
44.
MSX1 is found to have a linkage with Witkop syndrome, also known as tooth and nail syndrome or nail dysgenesis and hypodontia since mutations in MSX1 were shown to be associated with tooth agenesis.
45.
As opposed to agenesis, which refers to the complete failure of an organ to develop, dysgenesis usually implies disordered development or malformation and in some cases represents the milder end of a spectrum of abnormalities.
46.
The Currarino triad ( OMIM 176450 ), due to an autosomal dominant mutation in the MNX1 gene, consists of a presacral mass ( usually a mature teratoma or anterior meningocele ), anorectal malformation and sacral dysgenesis.
47.
Another type of XX gonadal dysgenesis is known as 46, XX gonadal dysgenesis epibulbar dermoid, which follows the similar symptoms as the regular syndrome, though it also shows signs of epibulbar dermoid ( eye disorder ).
48.
Another type of XX gonadal dysgenesis is known as 46, XX gonadal dysgenesis epibulbar dermoid, which follows the similar symptoms as the regular syndrome, though it also shows signs of epibulbar dermoid ( eye disorder ).
49.
Recent advances in mammalian genetic research have made possible the understanding of a molecular basis for a number of dysfunctional mechanisms in both motile and primary cilia structures of the disorders and diseases are caused by ciliary dysgenesis and dysfunction.
50.
These are adrenal dysgenesis ( the gland has not formed adequately during development ), impaired steroidogenesis ( the gland is present but is biochemically unable to produce cortisol ) or adrenal destruction ( disease processes leading to glandular damage ).
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