41. It is not an immunosuppressant, however, but rather it acts as a shield against microglia . 42. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. 43. The quinolinic acid produced in microglia is then released and stimulates NMDA receptors resulting in excitatory neurotoxiticity. 44. Molecular mediators are released by neurons, microglia , oligodendrocyte lineage cells, synaptic function and neural plasticity. 45. Accumulation of minor neuronal damage that occurs during normal aging can transform microglia into enlarged and activated cells. 46. Activated microglia making PGE 2 can then sensitize nociceptive neurons as manifested by their lowered threshold to pain. 47. Unlike the CB 1 receptor, in the brain, CB 2 receptors are found primarily on microglia . 48. TREM2 interacts with DAP12 in microglia to trigger phagocytosis of amyloid beta peptide and apoptotic neurons without inflammation. 49. Here he performed in-depth analysis on the reaction patterns of scavenger cells ( reactive microglia ). 50. He first explored the application of statins in suppressing the inflammatory events in microglia , astroglia and macrophages.
