According to another study ( done by some of the same people cited at the bottom of paragraph 1 of this section ), as the phagosome forms or soon after it forms, it fuses with the ER to form an ER-phagosome mix compartment.
42.
An example of a TB infection that came under control : " M . tuberculosis " are engulfed by macrophages after being identified as foreign, but due to an immuno-escape mechanism peculiar to mycobacteria, TB bacteria are able to block the fusion of their enclosing phagosome with lysosomes which would destroy the bacteria.
43.
Although type I IFN is absolutely critical for resistance to viruses, there is growing literature about the negative role of type I interferon in host immunity mediated by STING . AT-rich stem-loop DNA motif in the " Plasmodium falciparum " and " Plasmodium berghei " genome and extracellular DNA from " Mycobacterium tuberculosis " have been shown to activate type I interferon through STING . Perforation of the phagosome membrane mediated by ESX1 secretion system allows extracellular mycobacterial DNA to access host cytosolic DNA sensors, thus inducing the production of type I interferon in macrophages.
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