To limit and direct the response to injury in the rats, the researchers used indomethacin, an anti-inflammatory drug; bacterial lipopolysaccharide, a drug that limits secretion of an immune system protein, and pregnenolone, a type of steroid.
42.
The placenta produces pregnenolone and progesterone from circulating cholesterol . 16?-OH-DHEA-S is then taken up by the placenta . which is subsequently converted into estriol by 17?-hydroxysteroid dehydrogenase and then secreted predominantly into the maternal circulation.
43.
The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme ( P450scc, CYP11A1 ), a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to give pregnenolone.
44.
In further research by their group, a single 400 mg dose of oral pregnenolone at 3 hours post-administration was found to result in a 3-fold elevation in serum levels of pregnenolone and a 7-fold increase in allopregnanolone levels.
45.
In further research by their group, a single 400 mg dose of oral pregnenolone at 3 hours post-administration was found to result in a 3-fold elevation in serum levels of pregnenolone and a 7-fold increase in allopregnanolone levels.
46.
As such 17?-hydroxypregenolone represents an intermediary in the ? 5 pathway that leads from pregnenolone to DHEA . 17?-Hydroxypregneolone is also converted to 17?-hydroxyprogesterone, a prohormone for glucocorticosteroids and androstenedione through the activity of 3?-hydroxysteroid dehydrogenase.
47.
It has long been known that progesterone, and its precursor compound, pregnenolone, are synthesized in the central nervous system by glial cells and appear to play roles in neurotransmission, helping signals get from one nerve to another, said the new report.
48.
But when wounded nerves were exposed to a chemical that inhibits the conversion of pregnenolone to progesterone, or exposed to RU-486, a chemical that blocks the action of progesterone, thickness of newly produced myelin sheaths were decreased significantly, they reported.
49.
Expression of the recombinant protein demonstrated 7alpha-hydroxylation activity for steroids ( DHEA, pregnenolone ) and oxysterols including 25-and 27-hydroxycholesterol, confirmed by knockout in mouse that abolished oxysterol hydroxylation in liver and brain and steroid hydroxylation in multiple tissues.
50.
According to Paula Begoun, the author of " Don't Go to the Cosmetics Counter Without Me " ( Beginning Press, $ 24.95 ), Eterna 27 " contains pregnenolone acetate, often derived from animal urine ."
How to say pregnenolone in Hindi and what is the meaning of pregnenolone in Hindi? pregnenolone Hindi meaning, translation, pronunciation, synonyms and example sentences are provided by Hindlish.com.
