41. Production of thrombin via massive bleeding causes the uterus to contract and leads to DIC. 42. The cellular effects of thrombin are mediated by protease-activated receptors ( PARs ). 43. It mediates thrombin -triggered phosphoinositide hydrolysis and is expressed in a variety of tissues. 44. F2RL3 is activated by thrombin and trypsin. 45. The highly negative charge density of heparin contributes to its very strong electrostatic interaction with thrombin . 46. The excess thrombin cleaves fibrinogen, which ultimately leaves behind multiple fibrin clots in the circulation. 47. It does not act on thrombin , trypsin or chymotrypsin and does not express fibrinolytic activity. 48. Other proteases also activate Factor Va, but this cleavage is primarily carried out by thrombin . 49. Thrombin also promotes further thrombin generation, and activates platelets, stimulating aggregation and granule release.50. Thrombin also promotes further thrombin generation, and activates platelets, stimulating aggregation and granule release.
