1. Direct thrombin inhibitors provides an excellent example of negative allosteric modulation. 2. Thrombin also promotes secondary fibrin-reinforcement of the platelet plug.3. Each molecule of Factor Xa can generate 1000 molecules of thrombin . 4. It therefore remains active and increases the rate of thrombin generation. 5. Thrombin is a potent platelet activator, acting through Gq and G12.6. Excess circulating thrombin results from the excess activation of the coagulation cascade. 7. Recombinant thrombin is available as a powder for reconstitution into aqueous solution. 8. It functions as an inhibitor of coagulation by inhibiting thrombin . 9. Inactivation of Factor V a thus practically halts the production of thrombin . 10. Several other direct thrombin inhibitors are derived chemically from hirudin.
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