collagenase sentence in Hindi
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- Activated MMP7 and APMA can increase the activity of collagenase-1, and MMP7 can also convert the latent progelatinase A to its active form.
- In adrenocortical cells the trophic hormone ACTH induces expression of TIMP-1 and the increase in TIMP expression is also associated with decreased collagenase activity.
- A genetically engineered version of a hormone secreted in pregnancy that allows a woman's skin to stretch, Relaxin works by boosting collagenase and decreasing collagen.
- A study where patients were treated with these collagenase injections showed a recurrence rate of 67 % in the MCP joint and 100 % in the PIP joint.
- As skin cells age, for example, their genes churn out more and more collagenase, an enzyme that breaks down proteins needed to keep wrinkles at bay.
- Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell.
- Collagenase injection is a nonsurgical option to treat Dupuytren s disease and it provides the benefits of avoiding the potential surgical complications such as nerve injury, hematoma and skin necrosis.
- In February 2010 the US Food and Drug Administration ( FDA ) approved injectable collagenase extracted from " Clostridium histolyticum " for the treatment of Dupuytren's contracture.
- The main categories listed by the International Dupuytren Society in order of stage of disease are Radiation Therapy, Needle Aponeurotomy ( NA ), Collagenase Injection ( Xiaflex ) and Hand Surgery.
- Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn 341-Phe, Asp 441-Leu and Gln 354-Thr in the aggrecan interglobular domain
- At one time, fairly early in the research for diabetes treatment by transplantation, Ficoll was used in an attempt to separate islets of Langerhans from enzyme ( collagenase ) digested human pancreatic tissue.
- With respect to the role of GIP in lipid metabolism, supraphysiological levels have shown a lipogenic action, however the action of collagenase in experimental protocols is known to degrade GIP / GIP receptors.
- Another study showed that release of HS-bound basic FGF in culture could be achieved through treatment with stromelysin, heparitinase I, rat collagenase and plasmin, and these proteolysis sites are illustrated in figure 1.
- Collagenase clostridium histolyticum ( marketed as Xiaflex by [ Auxilium ] ), a drug originally approved by the FDA to treat Dupuytren's contracture, is now an FDA approved injectable drug for treatment of Peyronie's disease.
- Papain as well as other proteases, including bromelain, collagenase, trypsin and thermolysin, have also been tried or used according to other reports on the use of proteases for debridement of wounds and burns without damaging healthy tissue.
- Certain MMPs including MMP-1, MMP-2, MMP-8, MMP-13, and MMP-14 have collagenase activity, meaning that, unlike many other enzymes, they are capable of degrading collagen I fibrils.
- :Cleavage of Asn 3-Gln, His 10-Leu and Ala 14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase
- The human MMP7 is located on chromosome 11 q22.3 . " MMP " genes are clustered in q region of human Chromosome 11 including " matrilysin, collagenase-1, stromelysin1, stromelysin-2, and metalloelastase " genes.
- During the early proliferative phase ( 0 12 months ) the tumors express proliferating cell nuclear antigen ( pericytesna ), vascular endothelial growth factor ( VEGF ), and type IV collagenase, the former two localized to both endothelium and pericytes, and the last to endothelium.
- VR-RNA regulates the toxin colA ( collagenase ) by base-pairing to colA mRNA, the 3'end of VR-RNA base-pairs to a region in the 5'UTR of the colA mRNA . This induces cleavage of the colA mRNA in the 5'UTR and leads to stabilisation of the mRNA and increased translation.
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