phenacetin sentence in Hindi
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- These combined analgesics contained aspirin or other NSAID with phenacetin, paracetamol, or salicylamide, and caffeine or codeine.
- Paracetamol is the active metabolite of phenacetin and acetanilide, both once popular as analgesics and antipyretics in their own right.
- The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such as phenacetin.
- The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin.
- It was first launched by Roche in 1933, containing initially pyrithyldione and phenacetin, widely used remedies for fever and pain.
- It has been shown to metabolize Bufuralol, progesterone, Dextromethorphan, methoxyresorufin, cortisol, Diclofenac, Phenacetin, and testosterone.
- As the use of phenacetin declined, so too did the prevalence of analgesic nephropathy as a cause of end-stage kidney disease.
- It is currently thought that the kidney toxicities of NSAIDs and the antipyretics phenacetin and paracetamol may combine to give rise to analgesic nephropathy.
- "' Analgesic nephropathy "'is injury to the kidneys caused by analgesic medications such as aspirin, phenacetin, and paracetamol.
- They noted that chronic users of phenacetin had an increased risk of developing specific kidney injuries, namely renal papillary necrosis and chronic interstitial nephritis.
- A committee of investigators reported in 2000 that there was insufficient evidence to suggest that non-phenacetin analgesics by themselves are associated with analgesic nephropathy.
- Introduced in the late 19th century, phenacetin was once a common component of mixed analgesics in parts of Europe, Australia, and the United States.
- Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.
- The risk is higher for phenacetin ( which was withdrawn from market in the United States ) and paracetamol ( acetaminophen ) compared to aspirin and other NSAIDs.
- With further reports of the increased risk of kidney injury with prolonged and excessive phenacetin use, however, phenacetin was banned in several countries between the 1960s and 1980s.
- With further reports of the increased risk of kidney injury with prolonged and excessive phenacetin use, however, phenacetin was banned in several countries between the 1960s and 1980s.
- The problem came to a head when a gay instructor attempted suicide by overdosing on APC ( aspirin, phenacetin, and caffeine ) tablets after being spurned by another soldier.
- He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.
- He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.
- COX-3 was actually discovered in 2002, and been found to be selectively inhibited by paracetamol, phenacetin, antipyrine, dipyrone, and some NSAIDs in rodent studies.
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