Loewi described the substance released by the vagus nerve as vagusstoff, which was later found to be acetylcholine.
3.
Thanks to this confluence of events, Loewi was able to describe the existence of " vagusstoff " and prove the existence of chemical synaptic transmission.
4.
Historically, the first approach to the concept of autopharmacology began with Henry Dale in the 1910s, discovered the role of acetylcholine in synaptic transmission, and later proved by Austrian physiologist Otto Loewi, to be the neurotransmitter involved in the proximal synapses of the autonomic nervous system ( initially named " Vagusstoff " by Loewi, and later identified as acetylcholine ).
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