If the mutation is in the same gene as the original mutation it is known as extragenic suppression or intergenic suppression.
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21 . Stumpf AN, Roggenkamp A, Hoffmann H . Specificity of enterobacterial repetitive intergenic consensus and repetitive extragenic palindromic polymerase chain reaction for the detection of clonality within the Enterobacter cloacae complex.
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The term was first used by Davis in 1949, " We here propose the name " phenome " for the sum total of extragenic, non-autoreproductive portions of the cell, whether cytoplasmic or nuclear.
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They also contain a unique family of repetitive extragenic palindromes called PhREPS whose role is unknown though it is theorised that the stem loop structures the PhREPS are capable of forming may play a role in transcription termination or genome stability.
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Some of the molecular methods used in species identification are repetitive extragenic palindromic sequence-based PCR, ribotyping, pulsed field gel electrophoresis ( PFGE ), random amplified polymorphic DNA, amplified fragment length polymorphism ( AFLP ), restriction and sequence analysis of tRNA and 16S-23S rRNA gene spacers and amplified 16S ribosomal DNA restriction analysis ( ARDRA ).
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