1. In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase. 2. ADP is the strongest adenine nucleotide activator of glutaminase . 3. Glutaminase has an important role in glial cells.4. Glutaminase has tissue-specific isoenzymes.5. Administration of antioxidants or glutaminase inhibitor can reduce this mitochondrial transition, and potentially also astrocyte remodeling. 6. One of the most important roles of glutaminase is found in the axonal terminals of neurons in the central nervous system. 7. The last clinical results were published in 2008, though not as DON monotherapy but in combination with a recombinant glutaminase . 8. Glutaminase is also expressed in the epithelial cells of the renal tubules, where the produced ammonia is excreted as ammonium ions.9. The structure of Glutaminase has been determined using X-ray diffraction to a resolution of up to 1.73 ? 10. Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate-glutamine cycle by the enzyme glutaminase .
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