1. There are at least four different glutathione peroxidase isozymes in animals. 2. Their activity is attributed to their mimicry of glutathione peroxidase activity. 3. The glutathione peroxidase family consists of 8 known human isoforms. 4. However, glutathione peroxidase 4 knockout mice die during early embryonic development. 5. GPx-5 belongs to the glutathione peroxidase family. 6. It acts as a mimic of glutathione peroxidase and can also react with peroxynitrite. 7. Glutathione ( GSH ) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase . 8. Glutathione peroxidase activity was found to be much lower in patients with relapsing-remitting multiple sclerosis.9. Glutathione peroxidase , a selenoenzyme, catalyzes the reduction of hydrogen peroxide and organic peroxides by glutathione.10. GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide.
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