Multi - locus dna fingerprint technique was used to check the chimerism of chimeric mouse generated by injecting es cells into blastocysts and to detect whether the chimeric mouse is a germ - line chimeras . the results indicated that : the multi - locus dna fingerprint with a new synthesized probe - jl - 02 , has enough polymerism and good stability , and should be very useful to monitor the chimerism in different tissues of es cell chimeric mouse and to check whether an es cell line has the capacity to enter the germ line , especially when involving strains that can not be discerned with coat color or biochemical markers
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