ganglioside sentence in Hindi
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- Inability of HEXB will lead to?-hexosaminidase defect and result in a group of recessive disorders called GM2 gangliosidoses, characterized by the accumulation of GM2 ganglioside.
- This protein is required for the normal function of beta-hexosaminidase A, a critical enzyme in the nervous system that breaks down a lipid called GM2 ganglioside.
- As a result, progressive damage caused by the resulting buildup of GM2 ganglioside leads to the destruction of nerve cells, causing the signs and symptoms associated with Sandhoff disease.
- A Michaelis complex consisting of a glutamate residue, a GalNAc residue on the G M2 ganglioside, and an aspartate residue leads to the formation of an oxazolinium ion intermediate.
- Gangliosides are lipids, components of cellular membranes, and the ganglioside GM2, implicated in Tay-Sachs disease, is especially common in the nervous tissue of the brain.
- Intracerebroventricular administration of the modified ?-hexosaminidase B to Sandhoff mode mice restored the ?-hexosaminidase activity in the brains, and reduced the GM2 ganglioside storage in the parenchyma.
- A ganglioside is a molecule consisting of ceramide bound to a small group of hexose-type sugars and containing various numbers of lipooligosaccharides ) that crossreact with human nerve cell gangliosides.
- In addition, it is involved in the synthesis of ganglioside GD1A from GM1B . The enzyme is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form.
- The ganglioside-converting enzyme plasma membrane ganglioside sialidase ( PMGS ), which is involved in the activation of TrkA at the tip of neutrites, is required for the elongation of axons.
- The ganglioside-converting enzyme plasma membrane ganglioside sialidase ( PMGS ), which is involved in the activation of TrkA at the tip of neutrites, is required for the elongation of axons.
- G refers to ganglioside, the M is for monosialic ( as in it has one sialic acid ), and 2 refers to the fact that it was the second monosialic ganglioside discovered.
- G refers to ganglioside, the M is for monosialic ( as in it has one sialic acid ), and 2 refers to the fact that it was the second monosialic ganglioside discovered.
- The protein encoded by this gene is a small glycolipid transport protein which acts as a substrate specific co-factor for the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.
- This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
- Nonetheless, the NGcGM3 ganglioside is highly expressed in several human cancers, including lung, breast, melanocytes, colon and neuroectodermal pediatric tumors, making this neoantigen an attractive target for cancer therapy.
- "' GM1 "'( "'monosialotetrahexosylganglioside "') the " prototype " ganglioside, is a member of the ganglio series of gangliosides which contain one sialic acid residue.
- Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.
- Meltzer said that although he had been aware of the ganglioside experiment, it wasn't until the boy's father presented him with greater detail and a strong desire to try it that he had seriously considered it.
- In his all-night search of the Net, after hours of clicking on reports with bleak scenarios, Lord found a report about the ganglioside drug in a paper written by a high-school senior for her English class.
- A "'ganglioside "'is a molecule composed of a glycosphingolipid ( ceramide and oligosaccharide ) with one or more sialic acids ( e . g . n-acetylneuraminic acid, NANA ) linked on the sugar chain.
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