The Haworth reaction is a classic method for the synthesis of tetralone.
2.
When the side chain is homologated by the Arndt Eistert reaction, subsequent cyclization affords 2-tetralone, derivatives.
3.
2-Tetralone is an intermediate in the syntheses of a variety of pharmaceutical drugs, such as the antidepressant napamezole.
4.
Examples of such procedures are described for benzaldehyde, 2-tetralone, citral, the ethyl ester of pyruvic acid and glyoxal.
5.
This results in the formation of "'3a "'which tautomerizes to the more stable "'3b "'to the sulfonic acid of tetralone.
6.
The synthesis of dezocine begins with the condensation of 1-methyl-7-methoxy-2-tetralone with 1, 5-dibromopentane through use of NaH or potassium tertbutylate.
7.
"The KMnO 4 oxidation of the 1-aryl-tetralins # was observed to give 4-hydroxy-4-aryltetralones # instead of the expected tetralone # previously reported.
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