1. Rarely, cancer may be present in a thyroglossal duct cyst. 2. Up to half of thyroglossal cysts are not diagnosed until adult life. 3. Once the thyroglossal duct involutes, the cells will begin to degenerate and disappear. 4. Very rarely, the persistent duct can become cancerous, called thyroglossal duct carcinoma. 5. Thyroglossal Duct Cysts are a birth defect.6. Three-fourths of abnormalities within a persistent thyroglossal duct involve the formation of a cyst. 7. Small accessory thyroid glands may in fact occur anywhere along the thyroglossal duct, from the Zuckerkandl's tubercle. 8. The pyramidal lobe is a remnant of the thyroglossal duct which usually wastes away during the thyroid gland's descent. 9. Some congenital swellings may not be discovered until later in life, such as a branchial cyst, dermoid cyst or thyroglossal cyst. 10. During a person's life, these cyst pockets can fill with fluids and mucus, enlarging when infected, presenting the thyroglossal cyst.
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