xanthine oxidase sentence in Hindi
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- Because xanthine oxidase is a metabolic pathway for uric acid formation, the xanthine oxidase inhibitor allopurinol is used in the treatment of gout.
- Xanthine oxidase also produces uric acid, which may act as both a prooxidant and as a scavenger of reactive species such as peroxynitrite.
- Drugs that may contribute to the cure or amelioration of hyperuricosuria include allopurinol which acts by inhibiting xanthine oxidase and reducing uric acid production.
- A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by aldehyde oxidase.
- The main source of reactive oxygen species ( ROS ) is the enzyme xanthine oxidase ( XO ) and this enzyme mainly occurs in the liver.
- At the moment, the subject of xanthine oxidase ( in homogenized milk ) is a very hot area of research of chronic degenerative disease processes.
- Allopurinol, which weakly inhibits xanthine oxidase, is an analog of hypoxanthine that is hydroxylated by xanthine oxidoreductase at the 2-position to give oxipurinol.
- Concerns that uptake of the protein xanthine oxidase is increased by homogenization, leading to hardening of the arteries ( atherosclerosis ), were raised in the 1970s.
- During severe liver damage, xanthine oxidase is released into the blood, so a blood assay for XO is a way to determine if liver damage has happened.
- Xanthinuria is a rare genetic disorder where the lack of xanthine oxidase leads to high concentration of xanthine in blood and can cause health problems such as renal failure.
- In mice with hyperuricemia, " Phellodendron amurense " ( whether raw or processed with salt ) reduced blood uric acid levels by inhibiting xanthine oxidase activity.
- In addition to inhibition of pro-inflammatory mediators, troxipide directly acts on the enzymes such as xanthine oxidase and myeloperoxidase that generate free oxygen radicals in gastric mucosa.
- Since xanthine oxidase is involved in the metabolism of 6-mercaptopurine, caution should be taken before administering allopurinol and 6-mercaptopurine, or its prodrug azathioprine, in conjunction.
- Reactive nitrogen species, such as peroxynitrite that xanthine oxidase can form, have been found to react with DNA, proteins, and cells, causing cellular damage or even toxicity.
- Xanthine oxidase ( XO ) is an iron molybdenum enzyme, so people with iron deficiency ( the most common cause of anemia in young women ) or molybdenum deficiency can experience hypouricemia.
- Most of the protein in the liver exists in a form with xanthine dehydrogenase activity, but it can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
- Superoxide is also deleterious when produced as a byproduct of mitochondrial respiration ( most notably by Complex I and Complex III ), as well as several other enzymes, for example xanthine oxidase.
- A study found that patients with chronic obstructive pulmonary disease ( COPD ) had a decrease in oxidative stress, including glutathione oxidation and lipid peroxidation, when xanthine oxidase was inhibited using allopurinol.
- The compound quercinol ( a chromene derivative ), isolated from the oak mazegill, has anti-inflammatory activity, and inhibits the enzymes cyclooxygenase 2, xanthine oxidase, and horseradish peroxidase.
- It is one of the cytochromes " b " 5 and belongs to the enzyme super-family of molybdenum oxotransferases that also includes DMSO reductase, xanthine oxidase, and nitrite reductase.
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