xanthine oxidase sentence in Hindi
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- Reactive nitrogen signaling, coupled with reactive oxygen species, have been found to be a central part of myocardial and vascular function, explaining why xanthine oxidase is being researched for links to cardiovascular health.
- One route is through the deamination by the enzyme guanine deaminase to 6-thioxanthine, which has minimal anti-neoplastic activity, then by oxidation by xanthine oxidase of the thioxanthine to thiouric acid.
- Causes of kidney disease include deposition of the IgA antibodies in the glomerulus, administration of analgesics, xanthine oxidase deficiency, toxicity of chemotherapy agents, and long-term exposure to lead or its salts.
- Sn mi�o w�n has been reported to lower serum and liver uric acid concentration in mice with hyperuricemia, but not normal mice, by suppressing xanthine oxidase and downregulating production of mRNA for renal uric acid transporter mURAT1.
- Another reaction catalyzed by xanthine oxidase is the decomposition of S-Nitrosothiols ( RSNO ), a reactive nitrogen species, to nitric oxide ( NO ), which reacts with a superoxide anion to form peroxynitrite under aerobic conditions.
- Type II xanthinuria may result from a failure of the mechanism which inserts sulfur into the active sites of xanthine oxidase and aldehyde oxidase, a related enzyme with some overlapping activities ( such as conversion of allopurinol to oxypurinol ).
- The drugs and the enzymes they probe are as follows-caffeine ( probes CYP1A2, N-acetyltransferase 2, xanthine oxidase ), midazolam ( probes CYP3A ), omeprazole ( probes CYP2C19 ) and dextromethorphan ( probes CYP2D6 ).
- Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol, a xanthine oxidase inhibitor but not uricosuric, and probenecid, another uricosuric drug.
- "' Lesinurad "'( brand name "'Zurampic "', ) is a urate transporter inhibitor for treating hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone.
- Bovine xanthine oxidase ( from milk ) was originally thought to have a binding site to reduce cytochrome c with, but it has been found that the mechanism to reduce this protein is through XO's superoxide anion byproduct, with competitive inhibition by carbonic anhydrase.
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